CANDO indications and collaborations
Computational analysis of novel drug opportunities (CANDO) indications and collaborations Discover new cures and treatments with us!

Below is a complete list of the indications we are attacking and the collaborators with whom we are currently working. We are always on the look out for new collaborators, particularily those trying to cure underserved indications/diseases! If you think our computational pipeline could help you identify new therapeutics for your indications/diseases of interest, then we would like to hear from you.

Indication specfic collaborations

NumberIndication Putative primary cause CollaboratorInstitution~Proteins evaluated (Homo sapiens + other) Proteins implicated (as indicated by the collaborator)Current status (% complete)
ModellingPipelineBenchClinical
1 tuberculosisMycobacterium tuberculosis Michael StrongNational Jewish Health Center for Genes Environment and Health 50000 + 4000 TBD100% 100%0%0%
2 tuberculosisMycobacterium tuberculosis Prasit PalittapongarnpimRamathibodi Hospital, Mahidol University 50000 + 4000 TBD100% 100%0%0%
3 beta thalassemiaHomo sapiens (genetic) Surakameth MahasirimongkolNational Institute of Health Thailand 50000 3100% 100%0%0%
4 ebola infectionEbola virus Michael G. KatzeUniversity of Washington 50000 + 7 TBD100% 100%0%0%
5 dental cariesStreptococcus mutans/Lactobacillus Jeremy HorstUniversity of California San Francisco 2000 + 2000 TBD100% 100%100%0%
6 dengue feverDengue virus Scott MichaelFlorida Gulf Coast University 50000 + 14 TBD100% 100%70%0%
7 dengue feverDengue virus Karla KirkegaardStanford University 50000 + 14 TBD100% 100%70%0%
8 hepatitis CHepatitis C virus Lorne TyrrellUniversity of Alberta 50000 + 11 TBD100% 80%0%0%
9 hepatitis CHepatitis C virus Karla KirkegaardStanford University 50000 + 11 TBD100% 80%0%0%
10 adenovirus-associated indications (pharyngitis, acuate respiratory disease, pneumonia, pharyngoconjunctival fever, keratoconjuntivitis, cervicitis, urethritis, hemorrhagic cystitis, gasteroenteritis etc.)adenoviruses Jason SmithUniversity of Washington 50000 + 13 3100% 80%0%0%
11 yellow feveryellow fever virus Scott MichaelFlorida Gulf Coast University 50000 + 12 TBD100% 80%0%0%
12 viral encephalitisencephalitis virus(various strains) Scott MichaelFlorida Gulf Coast University 50000 + 12 TBD100% 80%0%0%
13 lupusHomo sapiens Keith ElkonUniversity of Washington 50000 1100% 90%0%0%
14 diabetes mellitus type IHomo sapiens (genetic) Gaurav ChopraDiabetes Center, UCSF 50000 TBD100% 60%0%0%
15 diabetes mellitus type IIHomo sapiens (genetic) Jay HeineckeUniversity of Washington 50000 100% 60%0%0%
16 diabetes insipidusHomo sapiens (genetic) Jay HeineckeUniversity of Washington 50000 100% 60%0%0%
17 geriatric-related indicationsHomo sapiens (genetic) Michael PetrascheckScripps 50000 TBD100% 50%0%0%
18 Dravet syndromeHomo sapiens (genetic) John OakleyUniversity of Washington 50000 3100% 50%0%0%
19 acquired immune deficiency syndromeHuman immunodeficiency virus James MullinsUniversity of Washington 50000 + 9 TBD100% 80%0%0%
20 hepatitis AHepatitis A virus Lorne TyrrellUniversity of Alberta 50000 + 9 TBD100% 80%0%0%
21 hepatitis BHepatitis B virus Lorne TyrrellUniversity of Alberta 50000 + 5 TBD100% 80%0%0%
22 influenza AInfluenza A virus Sissades TongsimaBIOTEC 50000 + 12 TBD100% 80%0%0%
23 influenza BInfluenza B virus TBDTBD 50000 + 11 TBD100% 80%0%0%
24 influenza CInfluenza C virus TBDTBD 50000 + 8 TBD100% 80%0%0%
25 herpes simplex 1Human herpesvirus 1 Michael LagunoffUniversity of Washington 50000 +74 TBD100% 80%0%0%
26 herpes simplex 2Human herpesvirus 2 Michael LagunoffUniversity of Washington 50000 + 74 TBD100% 80%0%0%
27 infectious mononucleosisEpstein-Barr virus TBDTBD 50000 +74 100% 80%0%0%
28 Kaposi's sarcomaHuman herpesvirus 8 Tim RoseUniversity of Washington 50000 + ?? TBD0% 0%0%0%
29 cancerHomo sapiens (neoplastic) Zhendong JinThe University of Iowa, College of Pharmacy 50000 TBD100% 70%0%0%
30 soft tissue infectionsPseudomonas aeruginosa Pradeep SinghUniversity of Washington 50000 + 5600 TBD60% 0%0%0%
31 hyponatremiaHomo sapiens (complex) Merrit MadukeStanford University 50000 TBD100% 100%0%0%
32 cholangiocarcinomasOpisthorchis viverrini Natini JinawathRamathibodi Hospital, Mahidol University 50000 + ?? 97100% 100%0%0%
33 gastric cancersHelicobacter pylori Natini JinawathRamathibodi Hospital, Mahidol University 50000 + 1500 150100% 60%0%0%
34 ovarian cancersHomo sapiens (neoplastic) Natini JinawathRamathibodi Hospital, Mahidol University 50000 24100% 60%0%0%
35 prostrate cancerHomo sapiens (neoplastic) Soranan ChantarangsuRamathibodi Hospital, Mahidol University 50000 TBD 100% 60%0%0%
36 lung cancerHomo sapiens (neoplastic) Ming YouMedical College of Wisconsin 50000 TBD100% 60%0%0%
37 malariaPlasmodium falciparum/vivax Yongyuth YuthavongBIOTEC 50000 + 5000 + 5000 350% 0%0%0%
38 malariaPlasmodium falciparum/vivax Wesley van VoorhisUniversity of Washington 50000 + 5000 + 5000 TBD50% 0%0%0%
39 primary billiary cirrhosisHomo sapiens (genetic) Andrew MasonUniversity of Alberta 50000 2100% 60%0%0%
40 cystic fibrosisHomo sapiens (genetic) Andrew MasonUniversity of Alberta 50000 TBD100% 60%0%0%
41 prionHomo sapiens (complex) Diego Rincon-LimasUniversity of Florida 50000 TBD100% 60%0%0%
42 Huntington'sHomo sapiens (complex) Diego Rincon-LimasUniversity of Florida 50000 TBD100% 60%0%0%
43 allergiesHomo sapiens (complex) Ted JardetzkyStanford University 50000 TBD100% 60%0%0%
44 Snakebite-induced tissue necrosissnakebite toxins Ponlapat RojnuckarinChulalongkorn University 50000 TBD100% 60%0%0%

Compound specific collaborations

NumberCompound(s)Name Institution
1silymarin Steve Polyak University of Washington
2cannobinoids To be determined NA
3phenylethylamines To be determined NA
4salvinorin A To be determined NA
5tryptamines To be determined NA

General collaborations

NumberDescription Name Institution
1personalized medicine Wasun Chantratita Ramathibodi Hospital, Mahidol University
2drug affinity responsive target stability (DARTS) Jing Huang University of California Los Angeles
3novel drug design Jun Liu John Hopkins University
4discovery of novel drugs from plant metabolites Gane Ka-Shu Wong University of Alberta
CANDO || Protinfo || Bioverse || Samudrala Computational Biology Research Group || cando.washington.edu