Acquired immunodeficiency syndrome (AIDS) is a pandemic indication caused by Human Immunodeficiency Virus (HIV), of which there there are two types. HIV is transmitted primarily via unprotected sexual intercourse, contaminated blood transfusions, hypodermic needles, and from mother to child during pregnancy, delivery or breastfeeding. As of 2010, approximately 34 million people are living with HIV globally.
Antiretroviral drugs target individual proteins in HIV, the primary pathogen implicated in AIDS. Associated opportunistic infections are treated according to cause. CANDO predictions were made targeting the canonical proteomes of HIV 1 and 2, taking into account the interaction signatures of the predicted compounds in the context of the human proteome as well as the protein structural universe.