Dengue is an infectious disease caused by dengue virus transmitted through Aedes mosquitoes. Dengue is endemic in more than 110 countries. It infects 50 to 390 million people worldwide a year, leading to half a million hospitalizations, and approximately 25,000 deaths annually.
There are no specific antiviral drugs for dengue.
Interactions between all proteins in the dengue proteome and a complete set of FDA approved compounds are predicted and ranked. Compounds are reranked based on their propensity to interact with the human proteome, such that compounds that specificaly target the dengue proteome over the human proteome are preferred.
The consensus ranked predictions using all information from all sources is tabulated below.
|Final Rank||Initial Rank (without information from human proteome)||Compound||Dengue protein target(s)||Cost||Quantity||Structure|